Extracorporeal Detoxification Methods and Hemostasis System for Ovarian Cancer Patients. Clinical Case

Introduction. Malignant tumors dominate in the picture of disability and mortality worldwide. One most frequent dangerous comorbid conditions is kidney injury. At same time, unfavorable incidence acute injury recorded multiple myeloma, leukemia, lymphoma and/or liver cancer malignant ovarian neoplasms. In this regard, vital importance choice tactics prevention thrombosis thromboembolic complications, as well individual approach to anticoagulant therapy regimen during renal replacement sessions, depending on underlying disease state hemostatic system. Aim. To evaluate effect calcium citrate veno-venous hemodiafi ltration sessions system a patient with progressive organ dysfunctions associated neoplasm. Materials methods. The methodology involved literature review case study assess hemostasis. Results discussion. clinical was assessed terms P-selectin (CD62), which characterizes platelet activation processes. It should be noted that patient, expression increased each session therapy, while aggregation values remained at level lower thresholds, indicates low probability coagulation initiation. However, due aggressive regulation by form production inflammatory mediators, microvesicles, tissue factor endothelial activation, attention paid molecular aspects regional coagulation. Conclusion. widespread use extracorporeal detoxification methods an independent risk not only for bleeding events, but may potentially contribute requires further detailed mechanisms hemostasis tumor evaluation various anticoagulation